Neurohypophyseal germinoma traced from its earliest stage via magnetic resonance imaging: case report

Surg Neurol. 2001 Oct;56(4):236-41. doi: 10.1016/s0090-3019(01)00575-4.


Background: We report a case in which magnetic resonance imaging (MRI) documented the formation of a neurohypophyseal germinoma from its earliest stage.

Case description: A 9-year-old girl presented with polyuria, polydipsia, and growth retardation. Urinary and endocrinological examination indicated diabetes insipidus (DI) and growth hormone deficiency. No clear evidence of a mass in the hypothalamo-pituitary area was apparent on the first MRI scan. Follow-up MRIs and endocrinological examinations revealed that a tumor, arising from the stalk and posterior lobe of the pituitary gland, formed a mass and caused anterior pituitary function to deteriorate. Histologic diagnosis was germinoma based on open biopsy.

Conclusion: Radiologic findings in this case indicated the primary site of this intrasellar germinoma to be the hypothalamo-neurohypophyseal region, designating this a "neurohypophyseal germinoma."

Publication types

  • Case Reports

MeSH terms

  • Child
  • Combined Modality Therapy
  • Disease Progression
  • Female
  • Germinoma / diagnosis*
  • Germinoma / pathology
  • Germinoma / surgery
  • Humans
  • Magnetic Resonance Imaging*
  • Neoplasm Staging
  • Pituitary Diseases / diagnosis*
  • Pituitary Diseases / pathology
  • Pituitary Diseases / surgery
  • Pituitary Neoplasms / diagnosis*
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / surgery