The influence of age on the response of major depression to electroconvulsive therapy: a C.O.R.E. Report

Am J Geriatr Psychiatry. 2001 Fall;9(4):382-90.


As part of a C.O.R.E., multi-site longitudinal study comparing continuation electroconvulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, > or =65 years; 46-64 years; and < or =45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Depressive Disorder, Major / therapy*
  • Electroconvulsive Therapy / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Remission Induction