Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia

J Nutr. 2001 Dec;131(12):3204-7. doi: 10.1093/jn/131.12.3204.


We examined the effect of daily consumption of dietary diacylglycerol (DG) oil on serum lipid concentrations in patients with diabetes whose serum triacylglycerol (TG) levels were persistently increased despite continuous nutritional counseling at the outpatient clinic. Patients (n = 16) were divided into DG and control groups (n = 8 each). DG was incorporated (target dose 10 g/d) by substituting DG oil (80 g DG/100 g oil) for the ordinary TG cooking oil used at home for 12 wk. The control group continued consuming ordinary TG cooking oil. Dietary records indicated that there were no differences between groups in total energy intake or percentage of energy from fat. In the DG group, TG intake decreased from 26.8 +/- 9.3 to 15.7 +/- 8.9 g/d, whereas DG intake increased from 0.3 +/- 0.1 to 10.6 +/- 3.9 g/d. No differences between groups were observed in body weight, total fat intake or total oil consumption throughout the study period. In the DG group, serum TG levels decreased 39.4% from 2.51 +/- 0.75 mmol/L to 1.52 +/- 0.28 mmol/L. Serum glycohemoglobin A(1c) (HbA(1c)) concentration also decreased 9.7%. In contrast, there were no changes in these variables in the control group. Serum total and HDL cholesterol were not affected in either group. These results indicate that DG oil may be useful as an adjunct to the standard diet therapy of fat restriction in the management of diabetics with hypertriglyceridemia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Blood Glucose / analysis
  • Body Mass Index
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Dietary Fats / administration & dosage*
  • Diglycerides / administration & dosage*
  • Energy Intake
  • Glycated Hemoglobin / analysis
  • Humans
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / diet therapy*
  • Triglycerides / blood*


  • Blood Glucose
  • Cholesterol, HDL
  • Dietary Fats
  • Diglycerides
  • Glycated Hemoglobin A
  • Triglycerides
  • Cholesterol