Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates

I V Dyuizen; P A Motavkin; V V Shorin

doi:10.1023/a:1013151625135

Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates

Bull Exp Biol Med. 2001 Sep;132(3):918-20. doi: 10.1023/a:1013151625135.

Authors

I V Dyuizen¹, P A Motavkin, V V Shorin

Affiliation

¹ Laboratory of Pharmacology, Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok. iduizen@yahoo.com

PMID: 11740593
DOI: 10.1023/a:1013151625135

Abstract

Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.

MeSH terms

Analgesics, Opioid / pharmacology
Animals
Brain / drug effects
Brain / metabolism
Cell Nucleus / enzymology
Cell Nucleus / metabolism
Heroin / metabolism
Heroin / pharmacology
NADPH Dehydrogenase / metabolism*
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Narcotics / pharmacology*
Neurons / metabolism
Nitric Oxide / metabolism
Raphe Nuclei / enzymology
Raphe Nuclei / metabolism*
Rats

Substances

Analgesics, Opioid
Narcotic Antagonists
Narcotics
Nitric Oxide
Naloxone
Heroin
NADPH Dehydrogenase