Regulatory role of cytokines in disseminated intravascular coagulation

Semin Thromb Hemost. 2001 Dec;27(6):639-51. doi: 10.1055/s-2001-18868.


Disseminated intravascular coagulation (DIC) can complicate a number of diseases. DIC in the setting of sepsis is considered to result from strong activation of the coagulation system and concurrent inhibition of fibrinolysis and other anticoagulant pathways. Cytokines have been implicated as important mediators in these hemostatic alterations. This article summarizes recent insights into which cytokines are likely to be involved in the procoagulant response to systemic infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Coagulation
  • Cytokines / blood
  • Cytokines / physiology*
  • Disseminated Intravascular Coagulation / blood*
  • Disseminated Intravascular Coagulation / etiology
  • Disseminated Intravascular Coagulation / physiopathology
  • Humans
  • Sepsis / blood
  • Sepsis / complications


  • Cytokines