Cervical coinfection with human papillomavirus (HPV) types as a predictor of acquisition and persistence of HPV infection

J Infect Dis. 2001 Dec 15;184(12):1508-17. doi: 10.1086/324579. Epub 2001 Dec 3.


Interest in coinfection with multiple types of human papillomavirus (HPV) has increased in response to the possibility of vaccination and the discovery that the host immune response appears to be mainly type specific. This study attempts to document the occurrence of coinfection with multiple HPV types and to determine whether these coinfections predicted acquisition or persistence of other HPV types in a prospective cohort of women in Brazil. Multiple HPV types were detected at the same visit in one-fifth of all women who tested positive for HPV at any time. Acquisition of an HPV infection was more likely among women with any HPV type detected on study entry. Persistence of HPV infection, the true precursor of cervical abnormalities, was independent of coinfection with other HPV types. Given the increasing prominence of HPV vaccination as a potential preventive approach, it is imperative that additional insights on cross-type protection be obtained from longer-term longitudinal investigations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Brazil / epidemiology
  • Cohort Studies
  • DNA, Viral / analysis
  • Female
  • Humans
  • Middle Aged
  • Papillomaviridae / classification*
  • Papillomaviridae / growth & development
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / virology*
  • Predictive Value of Tests
  • Prevalence
  • Prospective Studies
  • Tumor Virus Infections / epidemiology
  • Tumor Virus Infections / virology*
  • Uterine Cervical Diseases / epidemiology
  • Uterine Cervical Diseases / virology*
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / virology*


  • DNA, Viral