Plasmodium Falciparum: PFCRT and DHFR Mutations Are Associated With Failure of Chloroquine Plus Proguanil Prophylaxis in Travelers

J Infect Dis. 2001 Dec 15;184(12):1633-4. doi: 10.1086/324616.

Publication types

  • Letter

MeSH terms

  • Animals
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Chloroquine / pharmacology
  • Chloroquine / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Malaria, Falciparum / parasitology
  • Malaria, Falciparum / prevention & control*
  • Membrane Proteins / genetics*
  • Membrane Transport Proteins
  • Mutation
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / genetics*
  • Proguanil / pharmacology
  • Proguanil / therapeutic use*
  • Protozoan Proteins
  • Tetrahydrofolate Dehydrogenase / genetics*
  • Travel
  • Treatment Failure

Substances

  • Antimalarials
  • Membrane Proteins
  • Membrane Transport Proteins
  • PfCRT protein, Plasmodium falciparum
  • Protozoan Proteins
  • Chloroquine
  • Tetrahydrofolate Dehydrogenase
  • Proguanil