PIP3, PIP2, and cell movement--similar messages, different meanings?

Dev Cell. 2001 Dec;1(6):743-7. doi: 10.1016/s1534-5807(01)00086-7.


The inositol lipids PI(4,5)P(2) and PI(3,4,5)P(3) are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P(3) seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P(2) appears to be present at too high a concentration and homogeneous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P(2) acts permissively, restricting new actin polymerization to the region of the plasma membrane.

Publication types

  • Review

MeSH terms

  • Actins / metabolism*
  • Cell Membrane / metabolism
  • Cell Movement / physiology*
  • Cytoskeleton / metabolism
  • Neutrophils / metabolism
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*
  • Phosphatidylinositols / metabolism*
  • Polymers / chemistry
  • Proteins / metabolism
  • Second Messenger Systems / physiology*
  • Signal Transduction / physiology
  • Wiskott-Aldrich Syndrome Protein


  • Actins
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositols
  • Polymers
  • Proteins
  • Wiskott-Aldrich Syndrome Protein
  • phosphoinositide-3,4,5-triphosphate