Review
doi: 10.1038/414792a.
beta-Cell death during progression to diabetes
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- PMID: 11742411
- DOI: 10.1038/414792a
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Review
beta-Cell death during progression to diabetes
Nature.
.
Abstract
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
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