beta-Cell death during progression to diabetes

Nature. 2001 Dec 13;414(6865):792-8. doi: 10.1038/414792a.

Abstract

The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Autoimmunity
  • Cell Death
  • Diabetes Mellitus, Type 1 / etiology
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / pathology*
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / pathology*
  • Disease Progression
  • Humans
  • Inflammation Mediators / metabolism
  • Islets of Langerhans / immunology
  • Islets of Langerhans / pathology*
  • Mice
  • T-Lymphocytes / immunology

Substances

  • Autoantigens
  • Inflammation Mediators