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, 414 (6865), 813-20

Biochemistry and Molecular Cell Biology of Diabetic Complications

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Biochemistry and Molecular Cell Biology of Diabetic Complications

M Brownlee. Nature.

Abstract

Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

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