Expression analysis of PDGF-C in adult and developing mouse tissues

Mech Dev. 2002 Jan;110(1-2):187-91. doi: 10.1016/s0925-4773(01)00560-3.


There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems. Analysis in adult tissues showed that PDGF-C was mainly expressed in kidney, testis, liver, heart and brain. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, and in several other tissues, particularly at sites of developing epidermal openings. PDGF-C may therefore have unique functions during tissue development and maintenance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphokines*
  • Male
  • Mice
  • Organ Specificity
  • Platelet-Derived Growth Factor / genetics*
  • Platelet-Derived Growth Factor / metabolism
  • Proto-Oncogene Proteins c-sis / genetics
  • Receptor, Platelet-Derived Growth Factor alpha / genetics


  • Lymphokines
  • Pdgfd protein, mouse
  • Platelet-Derived Growth Factor
  • Proto-Oncogene Proteins c-sis
  • platelet-derived growth factor A
  • platelet-derived growth factor C
  • Receptor, Platelet-Derived Growth Factor alpha