Abstract
Further studies on leaves of Annona montana led to isolation of one iso-acetogenin, montanacin G, three pairs of acetogenins, montanacin H-J and 34-epi-montanacin H-J, together with four known acetogenins, gigantetrocins A and B, annonacin and cis-annonacin. Montanacin G belongs to the iso-acetogenin group with a terminal 2,4-trans-ketolactone unit. Montanacin H-J and 34-epi-montanacin H-J contain the rare gamma-hydroxy-gamma-methyl-gamma-lactone moiety. The cytotoxic activities of these compounds, together with previously reported acetogenins, montanacins B and C, were examined against Meth-A and LLC tumor cell lines in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Animals
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Annonaceae*
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Cell Division / drug effects
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Fatty Alcohols / chemistry
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology
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Furans / chemistry*
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Furans / isolation & purification
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Furans / pharmacology
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Magnetic Resonance Spectroscopy
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Leaves / chemistry
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Trees / chemistry
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Tumor Cells, Cultured
Substances
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Fatty Alcohols
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Furans
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Plant Extracts
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4-Butyrolactone