Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana

Planta Med. 2001 Dec;67(9):847-52. doi: 10.1055/s-2001-18847.

Abstract

Further studies on leaves of Annona montana led to isolation of one iso-acetogenin, montanacin G, three pairs of acetogenins, montanacin H-J and 34-epi-montanacin H-J, together with four known acetogenins, gigantetrocins A and B, annonacin and cis-annonacin. Montanacin G belongs to the iso-acetogenin group with a terminal 2,4-trans-ketolactone unit. Montanacin H-J and 34-epi-montanacin H-J contain the rare gamma-hydroxy-gamma-methyl-gamma-lactone moiety. The cytotoxic activities of these compounds, together with previously reported acetogenins, montanacins B and C, were examined against Meth-A and LLC tumor cell lines in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • 4-Butyrolactone / pharmacology
  • Animals
  • Annonaceae*
  • Cell Division / drug effects
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology
  • Furans / chemistry*
  • Furans / isolation & purification
  • Furans / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Leaves / chemistry
  • Trees / chemistry
  • Tumor Cells, Cultured

Substances

  • Fatty Alcohols
  • Furans
  • Plant Extracts
  • 4-Butyrolactone