Immunoreactivity for p27(KIP1) and cyclin E is an independent predictor of survival in primary gastric non-Hodgkin's lymphoma

Int J Cancer. 2001 Nov;94(4):599-604. doi: 10.1002/ijc.1509.


Our aim was to assess the prognostic implications of the expression of p27(KIP1) and cyclin E in gastric lymphoma. We investigated the prognostic value of the immunoreactivity of these molecules in 92 cases of primary gastric lymphoma: 34 LGMLs, 24 DLCLMLs and 34 DLCLs. p27 was positive in 88% of LGMLs, 71% of DLCLMLs and 32% of DLCLs (p = 0.004); cyclin E was positive in 9%, 33% and 59% of cases, respectively (p < 0.00001). p27/cyclin E immunoreactivity significantly correlated with histologic category, stage and LDH serum level. p27 immunoreactivity was significantly associated with better survival, whereas cyclin E reactivity was significantly related to worse outcome. Five-year CSS was 94% for patients with p27(+)/cyclin E(-) phenotype (n = 42), 79% for p27(+)/cyclin E(+) (n = 14) or p27(-)/cyclin E(-) (n = 16) phenotype and 60% for p27(-)/cyclin E(+) phenotype (n = 16) (p = 0.02). The prognostic role of p27/cyclin E expression was confirmed when analyzed separately within LGMLs and large-cell lymphomas. Immunoreactivity for p27 and cyclin E is an independent predictor of survival in PGLs that may be an adjunctive tool in identifying high-risk patients. It correlates with histologic category, stage and LDH serum level. p27(-)/cyclin E(+) phenotype is associated with worse survival, probably due to a synergistic effect of both cell-cycle defects. The predictive role of these molecules within each histologic group of PGLs deserves to be confirmed in larger series.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Cell Cycle Proteins / biosynthesis
  • Cell Cycle Proteins / immunology*
  • Cell Nucleus / metabolism
  • Cyclin E / biosynthesis
  • Cyclin E / immunology*
  • Cyclin-Dependent Kinase Inhibitor p27
  • Female
  • Humans
  • Immunohistochemistry
  • L-Lactate Dehydrogenase / blood
  • Lymphoma, Non-Hodgkin / diagnosis
  • Lymphoma, Non-Hodgkin / immunology*
  • Lymphoma, Non-Hodgkin / mortality*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Phenotype
  • Prognosis
  • Risk Factors
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / mortality
  • Tumor Suppressor Proteins / biosynthesis
  • Tumor Suppressor Proteins / immunology*


  • Cell Cycle Proteins
  • Cyclin E
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • L-Lactate Dehydrogenase