The JAK/STAT Pathway and Drosophila Development

Bioessays. 2001 Dec;23(12):1138-47. doi: 10.1002/bies.10016.

Abstract

The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Drosophila / embryology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology
  • Extremities / embryology
  • Eye / embryology
  • Glycoproteins / genetics
  • Glycoproteins / metabolism
  • Glycoproteins / physiology
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Insect Proteins / physiology*
  • Janus Kinases
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / physiology*
  • STAT Transcription Factors
  • Sex Determination Processes
  • Signal Transduction / physiology*
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Transcription Factors*
  • Wings, Animal / embryology

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Glycoproteins
  • Insect Proteins
  • STAT Transcription Factors
  • Stat92E protein, Drosophila
  • Trans-Activators
  • Transcription Factors
  • upd1 protein, Drosophila
  • Protein-Tyrosine Kinases
  • Janus Kinases
  • hop protein, Drosophila