Therapy of postoperative stroke: report of intra-arterial thrombolysis of a hyperacute embolic stroke 5 days following CABG

Catheter Cardiovasc Interv. 2001 Nov;54(3):339-41. doi: 10.1002/ccd.1295.


Intra-arterial (IA) recombinant tissue plasminogen activator (rt-PA) is an investigational treatment for acute stroke. We report a case of IA thrombolysis of a hyperacute middle cerebral artery stroke 5 days after coronary artery bypass graft surgery. Despite a serious extracranial bleeding complication (hemothorax), immediate thrombolysis with IA rt-PA led to near complete resolution of the neurological deficit and a favorable outcome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Coronary Artery Bypass
  • Humans
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Infarction, Middle Cerebral Artery / etiology*
  • Infusions, Intra-Arterial
  • Male
  • Postoperative Complications / drug therapy*
  • Postoperative Complications / etiology*
  • Thrombolytic Therapy
  • Tissue Plasminogen Activator / therapeutic use
  • Tomography, X-Ray Computed


  • Tissue Plasminogen Activator