Four cases of "locked-in" syndrome and review of the literature

Bull Los Angeles Neurol Soc. 1975 Apr;40(2):60-70.


The clinical features, pathology, the autopsy studies, EEG correlation, and the cause of death were discussed. The difference between the locked-in syndrome and classical akinetic mutism was discussed. The importance of reaching a correct diagnosis was stressed to allow a different nursing care program for the conscious "locked-in" patient. Two of our cases were short-term survival, two were long-term survival, one of whom (Case 4) is still living and is the longest survival reported in the literature.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Basilar Artery
  • Electroencephalography
  • Humans
  • Intracranial Embolism and Thrombosis* / complications
  • Intracranial Embolism and Thrombosis* / pathology
  • Male
  • Medulla Oblongata / pathology
  • Middle Aged
  • Mutism / etiology
  • Pons / blood supply*
  • Quadriplegia / etiology
  • Syndrome
  • Vertebral Artery