Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children

Emerg Infect Dis. Sep-Oct 2001;7(5):832-6. doi: 10.3201/eid0705.017510.

Abstract

Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antibodies, Bacterial / blood
  • Antibodies, Bacterial / immunology
  • Antigens, Bacterial / classification
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology
  • Bacterial Proteins / classification*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / immunology
  • Child, Preschool
  • Colombia
  • DNA, Bacterial / analysis
  • Humans
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines* / immunology
  • Polymerase Chain Reaction
  • Rabbits
  • Serotyping
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / immunology
  • Streptococcus pneumoniae / isolation & purification
  • Streptococcus pneumoniae / pathogenicity

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • DNA, Bacterial
  • Pneumococcal Vaccines
  • pneumococcal surface protein A