Multidrug-resistant tuberculosis in prison inmates, Azerbaijan

Emerg Infect Dis. Sep-Oct 2001;7(5):855-61. doi: 10.3201/eid0705.017514.

Abstract

In a tuberculosis (TB) program in the Central Penitentiary Hospital of Azerbaijan, we analyzed 65 isolates of Mycobacterium tuberculosis by IS6110-based restriction fragment-length polymorphism (RFLP) and spoligotyping. From 11 clusters associated with 33 patients, 31 isolates had an IS6110-based banding pattern characteristic of the Beijing genotype of M. tuberculosis. In addition, 15 M. tuberculosis isolates with similar RFLP patterns constituted a single group by spoligotyping, matching the Beijing genotype. Multidrug resistance, always involving isoniazid and rifampin, was seen in 34 (52.3%) of 65 isolates, with 28 belonging to the Beijing genotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antitubercular Agents / pharmacology
  • Azerbaijan / epidemiology
  • Bacterial Typing Techniques
  • DNA Transposable Elements / genetics
  • DNA-Directed RNA Polymerases / genetics
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium tuberculosis / classification*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Oligonucleotides / analysis
  • Polymorphism, Restriction Fragment Length
  • Prisoners*
  • Tuberculosis, Multidrug-Resistant / epidemiology*
  • Tuberculosis, Multidrug-Resistant / microbiology
  • Tuberculosis, Multidrug-Resistant / transmission
  • Tuberculosis, Pulmonary / epidemiology*
  • Tuberculosis, Pulmonary / microbiology
  • Tuberculosis, Pulmonary / transmission

Substances

  • Antitubercular Agents
  • DNA Transposable Elements
  • Oligonucleotides
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit