Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder

J Neuropsychiatry Clin Neurosci. 2001 Fall;13(4):511-4. doi: 10.1176/jnp.13.4.511.

Abstract

The authors examined the brains of patients with borderline personality disorder (BPD) by using short echo time single voxel spectroscopy and found a significant 19% reduction of absolute N-acetylaspartate concentrations in the dorsolateral prefrontal cortex in BPD (P=0.01) compared with control subjects.

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / metabolism*
  • Blood Glucose / metabolism
  • Borderline Personality Disorder / diagnosis*
  • Borderline Personality Disorder / pathology
  • Brain Mapping
  • Corpus Striatum / pathology
  • Energy Metabolism / physiology*
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Prefrontal Cortex / pathology*
  • Reference Values

Substances

  • Blood Glucose
  • Aspartic Acid
  • N-acetylaspartate