Unilateral periodic limb movements during sleep in corticobasal degeneration

Mov Disord. 2001 Nov;16(6):1180-3. doi: 10.1002/mds.1227.


Periodic limb movements in sleep (PLM) have been associated with several degenerative disorders and other focal or diffuse diseases. We present a patient with clinical diagnosis of corticobasal degeneration and sleep complaints, in whom video recording and polygraphic study confirmed the presence of right PLM. The unilaterality of the movements and the positron emission tomography findings (hypometabolism in the left frontoparietal, basal ganglia, and thalamic areas) suggest that the loss of inhibitory descending central pathways, with origin in the cortex or basal ganglia, may be involved in the pathogenesis of PLM.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Basal Ganglia Diseases / complications
  • Basal Ganglia Diseases / diagnosis*
  • Basal Ganglia Diseases / pathology
  • Basal Ganglia Diseases / physiopathology
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Dominance, Cerebral
  • Humans
  • Male
  • Neurodegenerative Diseases / complications
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / physiopathology
  • Nocturnal Myoclonus Syndrome / etiology*
  • Nocturnal Myoclonus Syndrome / physiopathology
  • Polysomnography / methods
  • Sleep Initiation and Maintenance Disorders / etiology
  • Tomography, Emission-Computed