Constituents and pharmacological effects of Eucommia and Siberian ginseng

Acta Pharmacol Sin. 2001 Dec;22(12):1057-70.

Abstract

The bark and leaves of Eucommia ulmoides Oliv (Eucommiaceae) and "Siberian ginseng" (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim (Acanthopanax senticosus Harms) have been used as tonic and anti-stress drug. The extracts of Eucommia showed anti-hypertensive, anti-complementary, anti-oxidative, and anti-gastric ulcer effects, and promoting collagen synthesis, accelating granuloma formation, and other pharmacological effects. The Siberian ginseng exhibited anti-fatigue, anti-stress, immuno-enhancing effect, CNS activity, and anti-depressive effect. By now, 40, 28, and 10 compounds have been isolated from Eucommia ulmoides bark, Eucommia ulmoides leaves, and Siberian ginseng, respectively, and their structures were elucidated. Their pharmacological activities were mainly due to lignans and iridoid glycosides.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Anti-Ulcer Agents / pharmacology
  • Antihypertensive Agents / pharmacology*
  • Antioxidants / pharmacology
  • Collagen / biosynthesis
  • Collagen / drug effects
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • Depression / drug therapy
  • Eleutherococcus / chemistry*
  • Eucommiaceae / chemistry*
  • Fatigue / drug therapy
  • Furans / isolation & purification
  • Furans / pharmacology
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Humans
  • Iridoid Glucosides
  • Iridoids / isolation & purification
  • Iridoids / pharmacology
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Stress, Physiological / drug therapy

Substances

  • Adjuvants, Immunologic
  • Anti-Ulcer Agents
  • Antihypertensive Agents
  • Antioxidants
  • Coumarins
  • Furans
  • Glucosides
  • Iridoid Glucosides
  • Iridoids
  • Lignans
  • Plant Extracts
  • syringaresinol
  • geniposidic acid
  • isofraxidin
  • Collagen