A new family of CoA-transferases

FEBS Lett. 2001 Dec 14;509(3):345-9. doi: 10.1016/s0014-5793(01)03178-7.


CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria, Anaerobic / enzymology*
  • Bacterial Proteins / classification
  • Bacterial Proteins / metabolism
  • Binding, Competitive
  • Coenzyme A-Transferases / chemistry
  • Coenzyme A-Transferases / classification*
  • Coenzyme A-Transferases / metabolism*
  • Kinetics
  • Substrate Specificity
  • Thiolester Hydrolases / classification
  • Thiolester Hydrolases / metabolism


  • Bacterial Proteins
  • Coenzyme A-Transferases
  • Thiolester Hydrolases
  • bile acid-CoA hydrolase