Getting your Pax straight: Pax proteins in development and disease

Trends Genet. 2002 Jan;18(1):41-7. doi: 10.1016/s0168-9525(01)02594-x.

Abstract

The Pax gene family encodes a group of transcription factors that have been conserved through millions of years of evolution and play roles in early development. Pax proteins have been implicated as regulators of organogenesis and as key factors in maintaining pluripotency of stem cell populations during development. Mutations of the Pax genes cause profound developmental defects in organisms as diverse as flies, mice and humans. Here, we review crucial and illustrative roles of Pax gene products in cell-fate specification and developmental biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Development
  • Eye / growth & development
  • Hematopoiesis
  • Humans
  • Islets of Langerhans / growth & development
  • Kidney / growth & development
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal / growth & development
  • Neoplasms / genetics
  • Neural Crest / embryology
  • Thyroid Gland / growth & development
  • Transcription Factors / genetics*
  • Transcription Factors / physiology

Substances

  • Transcription Factors