In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant Plasmodium falciparum

Antimicrob Agents Chemother. 2002 Jan;46(1):225-8. doi: 10.1128/AAC.46.1.225-228.2002.

Abstract

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / antagonists & inhibitors
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents / pharmacology
  • Antimalarials / pharmacology*
  • Chloroquine / pharmacology
  • Drug Combinations
  • Drug Resistance / physiology
  • Drug Synergism
  • Iron Chelating Agents / pharmacology*
  • Macrolides
  • Norfloxacin / pharmacology
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects*
  • Spermidine / analogs & derivatives*
  • Spermidine / pharmacology*
  • Tetracycline / pharmacology

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antimalarials
  • Drug Combinations
  • FR 160
  • Iron Chelating Agents
  • Macrolides
  • Chloroquine
  • Tetracycline
  • Norfloxacin
  • Spermidine