In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp

Sevtap Arikan; Mario Lozano-Chiu; Victor Paetznick; John H Rex

doi:10.1128/AAC.46.1.245-247.2002

In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp

Antimicrob Agents Chemother. 2002 Jan;46(1):245-7. doi: 10.1128/AAC.46.1.245-247.2002.

Authors

Sevtap Arikan¹, Mario Lozano-Chiu, Victor Paetznick, John H Rex

Affiliation

¹ Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA. sarikan@metu.edu.tr

Abstract

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and FUSARIUM: Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology*
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / pharmacology*
Aspergillus / drug effects*
Caspofungin
Drug Combinations
Drug Synergism
Echinocandins
Fusarium / drug effects*
Humans
Lipopeptides
Microbial Sensitivity Tests
Peptides*
Peptides, Cyclic*

Substances

Anti-Bacterial Agents
Antifungal Agents
Drug Combinations
Echinocandins
Lipopeptides
Peptides
Peptides, Cyclic
Amphotericin B
Caspofungin