Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)

Antimicrob Agents Chemother. 2002 Jan;46(1):255-8. doi: 10.1128/AAC.46.1.255-258.2002.

Abstract

Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.

MeSH terms

  • Amino Acid Sequence
  • Canada / epidemiology
  • Carbapenems / pharmacology
  • Cross Infection / epidemiology
  • Disease Outbreaks*
  • Humans
  • Molecular Sequence Data
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics*
  • Sequence Homology, Amino Acid
  • Spermidine / analogs & derivatives*
  • Spermidine / pharmacology
  • beta-Lactam Resistance / genetics*
  • beta-Lactamases / genetics

Substances

  • Carbapenems
  • FR 160
  • beta-lactamase IMP-1
  • beta-Lactamases
  • Spermidine

Associated data

  • GENBANK/AF318077