ENA-78 is an important angiogenic factor in idiopathic pulmonary fibrosis

Am J Respir Crit Care Med. 2001 Dec 15;164(12):2239-42. doi: 10.1164/ajrccm.164.12.2104106.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and often fatal disorder. Fibroplasia and deposition of extracellular matrix are dependent, in part, on angiogenesis and vascular remodeling. We obtained open lung biopsies from patients undergoing thoracic surgery for reasons other than interstitial lung disease (control) (n = 78) and from patients with IPF (n = 91). We found that levels of epithelial neutrophil-activating peptide 78 (ENA-78) were greater from tissue specimens of IPF patients, as compared with control subjects. When ENA-78 was depleted from IPF tissue specimens, tissue-derived angiogenic activity was markedly reduced. Immunolocalization of ENA-78 demonstrated that hyperplastic Type II pneumocytes and macrophages were the predominant cellular sources of ENA-78. These findings support the notion that ENA-78 may be an important additional factor that regulates angiogenic activity in IPF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiogenesis Inducing Agents / metabolism
  • Angiogenesis Inducing Agents / physiology*
  • Animals
  • Chemokine CXCL5
  • Chemokines, CXC*
  • Cornea / blood supply
  • Enzyme-Linked Immunosorbent Assay
  • Epithelium / metabolism
  • Epithelium / pathology
  • Fibroblasts / pathology
  • Humans
  • Interleukin-8 / analogs & derivatives*
  • Interleukin-8 / metabolism
  • Interleukin-8 / physiology*
  • Lung / blood supply*
  • Lung / metabolism
  • Lung / pathology
  • Macrophages / metabolism
  • Macrophages / pathology
  • Neovascularization, Pathologic* / physiopathology
  • Pulmonary Fibrosis / metabolism
  • Pulmonary Fibrosis / pathology
  • Pulmonary Fibrosis / physiopathology*
  • Rats
  • Rats, Long-Evans

Substances

  • Angiogenesis Inducing Agents
  • CXCL5 protein, human
  • Chemokine CXCL5
  • Chemokines, CXC
  • Interleukin-8