ProPred: prediction of HLA-DR binding sites

Bioinformatics. 2001 Dec;17(12):1236-7. doi: 10.1093/bioinformatics/17.12.1236.


ProPred is a graphical web tool for predicting MHC class II binding regions in antigenic protein sequences. The server implement matrix based prediction algorithm, employing amino-acid/position coefficient table deduced from literature. The predicted binders can be visualized either as peaks in graphical interface or as colored residues in HTML interface. This server might be a useful tool in locating the promiscuous binding regions that can bind to several HLA-DR alleles.

Availability: The server is available at


Supplementary information:

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Antigen Presentation / immunology*
  • Binding Sites
  • HLA-DR Antigens / immunology*
  • Humans
  • Peptides / immunology*
  • Software*


  • HLA-DR Antigens
  • Peptides