Regression of pulmonary metastatic disease associated with intralesional BCG therapy of intracutaneous melanoma metastases

Cancer. 1975 Oct;36(4):1305-8. doi: 10.1002/1097-0142(197510)36:4<1305::aid-cncr2820360417>;2-#.


A 77-year-old white man with 64 intracutaneous melanoma metastases and a pulmonary metastatic deposit was treated with immunotherapy. Over an 8-month period, 17 intracutaneous lesions were inoculated with BCG. All 17 injected lesions and all 47 uninjected intracutaneous lesions resolved; no new nodules appeared and the pulmonary metastasis regressed (greater than 50%). This is the first documented case of a pulmonary metastatic focus responding to intralesional BCG therapy of intracutaneous metastases.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / therapeutic use*
  • Humans
  • Lung Neoplasms / therapy*
  • Male
  • Melanoma / therapy*
  • Neoplasm Metastasis / therapy*
  • Skin Neoplasms / therapy


  • BCG Vaccine