Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities

J Antimicrob Chemother. 2002 Jan;49(1):165-8. doi: 10.1093/jac/49.1.165.

Abstract

Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequencing of the resistance determinant showed it to be erm(X) of corynebacterial origin located on the composite transposon Tn5432.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / drug therapy
  • Acne Vulgaris / genetics
  • Acne Vulgaris / microbiology
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Europe / epidemiology
  • Humans
  • Ketolides*
  • Lincosamides
  • Macrolides*
  • Propionibacteriaceae / drug effects*
  • Propionibacteriaceae / genetics
  • Propionibacteriaceae / isolation & purification
  • Streptogramin B / pharmacology*
  • Streptogramin B / therapeutic use

Substances

  • Anti-Bacterial Agents
  • DNA Transposable Elements
  • Ketolides
  • Lincosamides
  • Macrolides
  • Streptogramin B
  • telithromycin