Plasmid-mediated TEM-3 extended-spectrum beta-lactamase production in Salmonella typhimurium in Casablanca

J Antimicrob Chemother. 2002 Jan;49(1):169-72. doi: 10.1093/jac/49.1.169.


Isolates of extended-spectrum beta-lactamase (ESBL)-producing Salmonella typhimurium were recovered from children admitted to the IbnRochd University Hospital of Casablanca in 1994. These isolates produced TEM-3 as shown by PCR, isoelectric focusing and sequencing. Production of TEM-3 and resistance to gentamicin were encoded by a 10 kb plasmid that could be transferred by conjugation and transformation. This report extends the list of ESBLs produced by S. typhimurium and stresses the need for continuous surveillance of non-typhoidal Salmonella to adapt antibiotic treatment and preventive measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Gentamicins / pharmacology
  • Humans
  • Morocco
  • Plasmids / genetics*
  • Plasmids / isolation & purification
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / enzymology*
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / isolation & purification
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / isolation & purification


  • Anti-Bacterial Agents
  • Gentamicins
  • beta-lactamase TEM-3
  • beta-Lactamases