PharmGKB: the Pharmacogenetics Knowledge Base

Nucleic Acids Res. 2002 Jan 1;30(1):163-5. doi: 10.1093/nar/30.1.163.


The Pharmacogenetics Knowledge Base (PharmGKB; contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biotransformation / genetics*
  • Database Management Systems
  • Databases, Factual*
  • Drug Therapy
  • Enzymes / metabolism
  • Genetic Variation
  • Genome, Human
  • Humans
  • Information Storage and Retrieval
  • Internet
  • Pharmaceutical Preparations / metabolism
  • Pharmacogenetics*
  • Phenotype
  • Polymorphism, Single Nucleotide
  • User-Computer Interface


  • Enzymes
  • Pharmaceutical Preparations