Sentra, a database of signal transduction proteins

Nucleic Acids Res. 2002 Jan 1;30(1):349-50. doi: 10.1093/nar/30.1.349.


Sentra ( is a database of signal transduction proteins with the emphasis on microbial signal transduction. The database was updated to include classes of signal transduction systems modulated by either phosphorylation or methylation reactions such as PAS proteins and serine/threonine kinases, as well as the classical two-component histidine kinases and methyl-accepting chemotaxis proteins. Currently, Sentra contains signal transduction proteins from 43 completely sequenced prokaryotic genomes as well as sequences from SWISS-PROT and TrEMBL. Signal transduction proteins are annotated with information describing conserved domains, paralogous and orthologous sequences, and conserved chromosomal gene clusters. The newly developed user interface supports flexible search capabilities and extensive visualization of the data.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chemotaxis
  • Computer Graphics
  • Conserved Sequence
  • Databases, Protein*
  • Genome
  • Histidine Kinase
  • Information Storage and Retrieval
  • Internet
  • Methylation
  • Multigene Family
  • Phosphorylation
  • Prokaryotic Cells / metabolism*
  • Protein Kinases / chemistry
  • Protein Kinases / genetics
  • Protein Kinases / metabolism
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism
  • Sequence Homology
  • Signal Transduction*


  • Proteins
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Histidine Kinase