TTD: Therapeutic Target Database

Nucleic Acids Res. 2002 Jan 1;30(1):412-5. doi: 10.1093/nar/30.1.412.


A number of proteins and nucleic acids have been explored as therapeutic targets. These targets are subjects of interest in different areas of biomedical and pharmaceutical research and in the development and evaluation of bioinformatics, molecular modeling, computer-aided drug design and analytical tools. A publicly accessible database that provides comprehensive information about these targets is therefore helpful to the relevant communities. The Therapeutic Target Database (TTD) is designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3D structure, function, nomenclature, drug/ligand binding properties, drug usage and effects, and related literature for each target. This database can be accessed at and it currently contains entries for 433 targets covering 125 disease conditions along with 809 drugs/ligands directed at each of these targets. Each entry can be retrieved through multiple methods including target name, disease name, drug/ligand name, drug/ligand function and drug therapeutic classification.

MeSH terms

  • Databases, Nucleic Acid*
  • Databases, Protein*
  • Drug Therapy*
  • Humans
  • Information Storage and Retrieval
  • Internet
  • Ligands
  • Nucleic Acids / antagonists & inhibitors
  • Nucleic Acids / chemistry
  • Nucleic Acids / physiology
  • Proteins / antagonists & inhibitors
  • Proteins / chemistry
  • Proteins / physiology
  • User-Computer Interface


  • Ligands
  • Nucleic Acids
  • Proteins