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. 2001 Dec 21;294(5551):2542-5.
doi: 10.1126/science.1066707.

Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

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Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

A A Kiger et al. Science. .
Free article

Abstract

Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.

Comment in

  • Development. Staying a boy forever.
    Wasserman SA, DiNardo S. Wasserman SA, et al. Science. 2001 Dec 21;294(5551):2495-7. doi: 10.1126/science.1067914. Science. 2001. PMID: 11752564 No abstract available.

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