Perfusion MR imaging in gliomas: comparison with histologic tumor grade

Korean J Radiol. Jan-Mar 2001;2(1):1-7. doi: 10.3348/kjr.2001.2.1.1.


Objective: To determine the usefulness of perfusion MR imaging in assessing the histologic grade of cerebral gliomas.

Materials and methods: In order to determine relative cerebral blood volume (rCBV), 22 patients with pathologically proven gliomas (9 glioblastomas, 9 anaplastic gliomas and 4 low-grade gliomas) underwent dynamic contrast-enhanced T2*-weighted and conventional T1- and T2-weighted imaging. rCBV maps were obtained by fitting a gamma-variate function to the contrast material concentration versus time curve. rCBV ratios between tumor and normal white matter (maximum rCBV of tumor / rCBV of contralateral white matter) were calculated and compared between glioblastomas, anaplastic gliomas and low-grade gliomas.

Results: Mean rCBV ratios were 4.90 degrees +/- 1.01 for glioblastomas, 3.97 degrees +/- 0.56 for anaplastic gliomas and 1.75 degrees +/-1.51 for low-grade gliomas, and were thus significantly different; p <.05 between glioblastomas and anaplastic gliomas, p <.05 between anaplastic gliomas and low-grade gliomas, p <.01 between glioblastomas and low-grade gliomas. The rCBV ratio cutoff value which permitted discrimination between high-grade (glioblastomas and anaplastic gliomas) and low-grade gliomas was 2.60, and the sensitivity and specificity of this value were 100% and 75%, respectively.

Conclusion: Perfusion MR imaging is a useful and reliable technique for estimating the histologic grade of gliomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Astrocytoma / pathology*
  • Brain / pathology
  • Brain Neoplasms / pathology*
  • Cerebrovascular Circulation
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Glioblastoma / pathology*
  • Humans
  • Magnetic Resonance Imaging*
  • Male


  • Contrast Media
  • gadodiamide
  • Gadolinium DTPA