The human papillomavirus E6 protein and its contribution to malignant progression

Oncogene. 2001 Nov 26;20(54):7874-87. doi: 10.1038/sj.onc.1204869.


The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to the development of human malignancy many laboratories have focused their attention on identifying the cellular proteins with which E6 interacts. In this review we discuss these interactions in the light of their respective contributions to the malignant progression of HPV transformed cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Transformation, Neoplastic*
  • Cell Transformation, Viral / physiology*
  • Disease Progression
  • Humans
  • Oncogene Proteins, Viral / physiology*
  • Papillomaviridae / physiology*
  • Tumor Suppressor Protein p53 / physiology


  • Oncogene Proteins, Viral
  • Tumor Suppressor Protein p53