Calcium/calmodulin: a synaptic antidepressant?

Neuron. 2001 Dec 20;32(6):962-3. doi: 10.1016/s0896-6273(01)00546-3.


Synaptic depression contributes to short-term changes in synaptic efficacy during sustained activity. Sakaba and Neher (2001) have characterized two kinetically distinct pools of releasable vesicles whose depletion underlies depression at a CNS synapse. Calcium/calmodulin dramatically accelerates replenishment of one of these pools--and hence recovery from depression.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Calmodulin / physiology*
  • Synapses / physiology*
  • Synaptic Transmission / physiology*


  • Calmodulin
  • Calcium