Signaling at the growth cone: the scientific progeny of Cajal meet in Madrid

Neuron. 2001 Dec 20;32(6):981-4. doi: 10.1016/s0896-6273(01)00556-6.


I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cytoskeleton / physiology*
  • Growth Cones / physiology*
  • Signal Transduction / physiology*