Constituents of Lepidium meyenii 'maca'

Phytochemistry. 2002 Jan;59(1):105-10. doi: 10.1016/s0031-9422(01)00395-8.


The tubers of Lepidium meyenii contain the benzylated derivative of 1,2-dihydro-N-hydroxypyridine, named macaridine, together with the benzylated alkamides (macamides), N-benzyl-5-oxo-6E,8E-octadecadienamide and N-benzylhexadecanamide, as well as the acyclic keto acid, 5-oxo-6E,8E-octadecadienoic acid. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR spectroscopic analyses, including 1H-1H COSY, 1H-13C HMQC, 1H-13C HMBC and 1H-1H NOESY experiments, as well as from 1H-15N NMR HMBC correlations for macaridine and N-benzylhexadecanamide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • Amides / isolation & purification*
  • Lepidium / chemistry*
  • Polyunsaturated Alkamides
  • Pyridines / chemistry
  • Pyridines / isolation & purification*


  • Amides
  • N-benzyl-5-oxo-6,8-octadecadienamide
  • Polyunsaturated Alkamides
  • Pyridines
  • macaridine
  • N-benzylhexadecanamide