Chemokines and Alzheimer's disease

Neurobiol Aging. Nov-Dec 2001;22(6):909-13. doi: 10.1016/s0197-4580(01)00290-1.

Abstract

In recent years, increasing attention has been focused on chemokines as inflammatory mediators in the CNS. The limited number of studies that have investigated chemokine and chemokine receptor expression in Alzheimer's disease (AD) brain and in cell culture models seem to support a role for inflammation in AD pathogenesis. Here we provide a review of these studies, but in addition, point out the possible role of chemokines as communication molecules between neurons and microglia. Understanding neuron-microglia interactions is essential for understanding AD pathogenesis, and disturbances in chemokine-mediated intercellular communication may contribute toward a generalized impairment of microglial cell function.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology*
  • Brain Chemistry / physiology
  • Chemokines / metabolism
  • Chemokines / physiology*
  • Humans
  • Microglia / pathology

Substances

  • Chemokines