Salmonella entry into host cells: the work in concert of type III secreted effector proteins

Microbes Infect. Nov-Dec 2001;3(14-15):1293-8. doi: 10.1016/s1286-4579(01)01489-7.


Upon contact with intestinal epithelial cells, Salmonella enterica serovar spp. inject a set of bacterial proteins into host cells via the bacterial SPI-1 type III secretion system. SopE, SopE2 and SopB, activate CDC42 and Rac to initiate actin cytoskeleton rearrangements. SipA and SipC, two Salmonella actin-binding proteins, directly modulate host actin dynamics to facilitate bacterial uptake. SptP promotes the recovery of the actin cytoskeleton rearrangements by antagonizing CDC42 and Rac. Therefore, Salmonella-induced reversible actin cytoskeleton rearrangements are the result of two coordinated steps: (i) stimulation of host signal transduction to indirectly promote actin rearrangements and (ii) direct modulation of actin dynamics.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cattle
  • Cytoskeleton / metabolism
  • Cytoskeleton / microbiology
  • Gene Expression Regulation, Bacterial*
  • HeLa Cells
  • Humans
  • Mice
  • Salmonella Infections / microbiology*
  • Salmonella enterica / pathogenicity*
  • Signal Transduction*


  • Actins
  • Bacterial Proteins