Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity

Microbes Infect. Nov-Dec 2001;3(14-15):1327-34. doi: 10.1016/s1286-4579(01)01494-0.


Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Humans
  • Immunity, Innate*
  • Lipopolysaccharides / metabolism*
  • Mice
  • Salmonella Infections / microbiology
  • Salmonella typhimurium / enzymology*
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / pathogenicity*


  • Bacterial Proteins
  • Lipopolysaccharides
  • PhoQ protein, Bacteria
  • PhoR protein, Bacteria