Pulmonary response to polyurethane dust

Environ Health Perspect. 1975 Jun;11:109-13. doi: 10.1289/ehp.7511109.

Abstract

Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Bronchial Neoplasms / chemically induced
  • Cystadenoma / chemically induced
  • Dust
  • Environmental Exposure
  • Female
  • Intubation, Intratracheal
  • Lung / ultrastructure
  • Lung Diseases / chemically induced*
  • Lung Neoplasms / chemically induced
  • Lymphocytes / drug effects
  • Macrophages / drug effects
  • Male
  • Particle Size
  • Polyurethanes / administration & dosage
  • Polyurethanes / toxicity*
  • Pulmonary Emphysema / chemically induced
  • Pulmonary Fibrosis / chemically induced
  • Rats

Substances

  • Dust
  • Polyurethanes