The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels

Hum Immunol. 2001 Dec;62(12):1371-81. doi: 10.1016/s0198-8859(01)00346-9.


Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease primarily affecting the central nervous system. Of the many candidate polymorphic major histocompatibility complex (MHC) and non-MHC genes contributing to disease susceptibility, including those encoding effector (cytokines and chemokines) or receptor molecules within the immune system (MHC, TCR, Ig or FcR), human leukocyte antigen (HLA) class II genes have the most significant influence. In this article we put forward the hypothesis that the influence of HLA genes on the risk to develop MS is actually the sum of multiple antigen presenting cell (APC) and T-cell interactions involving HLA class I and class II molecules. This article will also discuss that, because of the genetic and immunologic similarity to humans, autoimmune models of MS in non-human primates are the experimental models "par excellence" to test this hypothesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Autoantibodies / immunology
  • Brain / immunology
  • Disease Models, Animal*
  • Encephalomyelitis, Autoimmune, Experimental / etiology
  • Encephalomyelitis, Autoimmune, Experimental / genetics
  • Female
  • Humans
  • Major Histocompatibility Complex* / immunology
  • Male
  • Mice
  • Multiple Sclerosis / genetics*
  • Myelin Sheath / immunology
  • Risk Factors
  • T-Lymphocytes / immunology


  • Autoantibodies