Risk of Human Immunodeficiency Virus Infection in Herpes Simplex Virus Type 2-seropositive Persons: A Meta-Analysis

J Infect Dis. 2002 Jan 1;185(1):45-52. doi: 10.1086/338231. Epub 2001 Dec 14.

Abstract

To determine the contribution of herpes simplex type 2 (HSV-2) infection to the risk of human immunodeficiency virus (HIV) acquisition, a systematic review of literature and data synthesis were done. Thirty-one studies addressed the risk of HIV infection in HSV-2-seropositive persons. For 9 cohort and nested case-control studies that documented HSV-2 infection before HIV acquisition, the risk estimate was 2.1 (95% confidence interval, 1.4-3.2). Thus, the attributable risk percentage of HIV to HSV-2 was 52%, and the population attributable risk percentage was 19% in populations with 22% HSV-2 prevalence but increased to 47% in populations with 80% HSV-2 prevalence. For 22 case-control and cross-sectional studies, the risk estimate was 3.9 (95% confidence interval, 3.1-5.1), but the temporal sequence of the 2 infections cannot be documented. Control strategies for HSV-2 need to be incorporated into control of sexually transmitted infections as a strategy for HIV prevention.

Publication types

  • Meta-Analysis
  • Research Support, U.S. Gov't, P.H.S.
  • Systematic Review

MeSH terms

  • Antibodies, Viral / blood*
  • Case-Control Studies
  • Cohort Studies
  • Female
  • HIV Infections / epidemiology
  • HIV Infections / etiology*
  • Herpes Genitalis / blood*
  • Herpes Genitalis / complications*
  • Herpes Genitalis / epidemiology
  • Humans
  • Male
  • Risk Factors

Substances

  • Antibodies, Viral