An intestinal disease produced experimentally by a prostaglandin deficiency

Gastroenterology. 1975 Oct;69(4):1045-7.


Several prostaglandins were found to prevent development of multiple ulcertions of the small intestine, produced in rats by nonsteroidal antiinflammatory compounds such as indomethacin. The syndrome appears to be due to a prostaglandin deficiency produced by indomethacin; treatment with a prostaglandin prevents such deficiency and thus protects the animals.

MeSH terms

  • Animals
  • Female
  • Intestinal Diseases / chemically induced*
  • Prostaglandin Antagonists / adverse effects*
  • Prostaglandins / deficiency*
  • Rats


  • Prostaglandin Antagonists
  • Prostaglandins