Cutaneous lymphadenoma

J Eur Acad Dermatol Venereol. 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x.


Lymphoepithelial neoplasms are biphasic tumours that contain both epithelial and lymphoid components. This heterogeneous group includes benign cutaneous lymphadenoma (CL), malignant lymphoepithelioma-like carcinoma of the skin and dermal thymus. We present two cases of CL in male subjects of 14 and 64 years of age. The latter man had a history of multiple basal cell carcinomas (BCCs) and solar keratoses. Histological sections of both tumours revealed similar features of an invasive non-ulcerated tumour with a mixed architecture of BCC and trichoepithelioma. Immunocytochemical examination revealed a biphasic epithelial tumour of follicular differentiation, possibly a variant of trichoepithelioma or a BCC. Within the epithelial islands there was a heavy infiltration that was confirmed as CD3-positive T cells and S-100-positive dendritic cells by immunocytochemistry.

Publication types

  • Case Reports

MeSH terms

  • Adenolymphoma / diagnosis
  • Adenolymphoma / pathology*
  • Adolescent
  • Biopsy, Needle
  • Carcinoma, Basal Cell / diagnosis
  • Carcinoma, Basal Cell / pathology*
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology*