Rosacea fulminans triggered by high-dose vitamins B6 and B12

J Eur Acad Dermatol Venereol. 2001 Sep;15(5):484-5. doi: 10.1046/j.1468-3083.2001.00308.x.


Rosacea fulminans is a rare variant of rosacea conglobata that occurs almost exclusively in women well past adolescence. The aetiology is unknown, although immunological, hormonal, and vascular factors have been suggested. We report the case of a 17-year-old girl with rosacea fulminans that was temporally associated with daily ingestion of high-dose vitamin B supplements. The onset was sudden and cosmetically disabling. The eruption improved when the vitamin supplement was discontinued and a therapeutic regimen including isotretinoin and methylprednisolone was introduced. It seems appropriate to consider the possibility of such a vitamin B-triggered condition in cases of subjects presenting new or exacerbating facial eruptions.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Dietary Supplements / adverse effects*
  • Dose-Response Relationship, Drug
  • Drug Eruptions / diagnosis
  • Drug Eruptions / etiology*
  • Facial Dermatoses / chemically induced
  • Facial Dermatoses / diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Risk Assessment
  • Rosacea / chemically induced*
  • Rosacea / diagnosis
  • Severity of Illness Index
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / adverse effects*
  • Vitamin B 6 / administration & dosage
  • Vitamin B 6 / adverse effects*


  • Vitamin B 6
  • Vitamin B 12